Twenty-nine years ago a study was published indicating the benefit of treatment with high-dose intravenous methylprednisolone in patients with acute spinal cord injury [1]. This has been the therapeutic attitude we have maintained for years. Since then, studies with conflicting data on the efficacy of this treatment had been published.

High-dose intravenous methylprednisolone study

In Neurology Liu et al [2] publish the result of a meta-analysis in which the results indicate that the use of intravenous methylprednisolone at high doses does not contribute to a better recovery and may cause complications (respiratory infection, gastrointestinal bleeding).

References:

[1] Bracken MB et al. N Engl J Med 1990;322: 1405-1411.
[2] Liu Z et al. Neurology 2019;93:1-10. doi:10.1212/WNL.0000000000007998.